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It was not until a genetically engineered strain of Pseudomonas denitrificans was used, in which eight of the genes involved in the biosynthesis of the vitamin had been overexpressed, that the complete sequence of methylation and other steps could be determined, thus fully establishing all the intermediates in the pathway
The B12 will be given where the doctor recommends
Because some people are asymptomatic or their symptoms can be similar to other nutritional deficiencies, a B12 deficiency may be hard to detect
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