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The ligands identified could be functionally divided into those which were formed as artifacts of extraction, natural products recognized as reaction product orthologues and biologically active metabolites that were not linked to any known enzyme activity related to the GSTs

Peptides like BPC-157, KPV, Thymosin Alpha-1, and Selank target specific pathways instead of masking symptoms

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Interestingly, missense mutations can occur within the catalytic domains of these two proteins, specifically in the GST-N domain of GDAP1 and the GTPase domain of MFN2 (Pijuan et al., 2022)