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The results showed that the treatment with Ru(II)-OH reduced the tumor volume by 35%, the treatment with NP2 by 66%, and the treatment with NP4 by 91% (Fig

Then, the oxidative stress markers, autophagy-related proteins and CYP19A1, StAR, and CYP17A1 expression in ovarian tissue were measured

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Concerns include reports of adverse events, some requiring hospitalization, that may be related to dosing errors or doses beyond what is in the FDA-approved drug label, which means using more product in a single dose, taking doses more frequently or increasing the amount more quickly (titration schedule)