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The escalation arms landed at 19.9% (6/9 mg) and 16.4% (3/6/9 mg), and the 3 mg and 6 mg fixed arms came in at 12.4% and 17.6%

Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

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