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This distribution suggests early adoption largely occurred in primary care settings rather than being driven primarily by specialty practices
In 1967, Luzzatto 12 postulated at least two sites of union of the NADP to the enzyme, with a condition of transition from low to high affinity when NADPs concentration increases, which means that there exist two possible forms of the enzyme, according to its affinity by the NADP
This phenotype was confirmed by targeted measurement of triglycerides in serum (Fig
Animals given high doses for extended periods didn't show obvious toxicity
CNS Drugs 33 , 209223 (2019)
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