glp-1 activation Schematic pathway showing release of insulin by GLP-1. Binding of Signaling Pathways of the GLP-1

For experiments in 384-well plates, wells were aspirated, rinsed with PBS and incubated with a fixative and staining solution containing 3.7% formaldehyde (Fisher Scientific, F75P-1GAL) and 5 g ml 1 Hoechst 33342, trihydrochloride, trihydrate (Invitrogen, H1399)

Vitamin C is well-known for its brightening and skin-rejuvenating effects

Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs

2B,C, Fig

doi:10.1186/s13048-024-01432-1