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In detail, epigenetic modifications lead to mutations on enzymes involved in metabolic pathways (among which the best noted are SDH, FH, and IDH) which in turn cause the accumulation of oncometabolites (as mentioned before, succinate, fumarate, and 2-hydroxyglutarate) that stimulates alterations in DNA and histone modifications [28]
Consistent sunscreen use is essential to maintain brightness and prevent darkening
You see, while most sunscreens help protect against UV ray exposure by blocking or scattering the rays, they don't do anything to stop that damage from happening which is why it's important to also use a product that contains an antioxidant that can help protect against free radical damage
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