The most frequent ( 10% incidence in any treatment group) TEAEs were thrombocytopenia (4% of episodes with carglumic acid + ammonia scavengers vs 5% with carglumic acid alone and 21% with ammonia scavengers alone), hyperglycaemia (4 vs 3 and 15%), hypokalaemia (0 vs 3 and 18%), coagulopathy (0 vs 3 and 15%), hypocalcaemia (0 vs 3 and 12%) and respiratory distress (0 vs 0 and 12%)
Oral bioavailability in humans has not been formally published, so any dose number here is a community-pattern reference, not a clinically validated dose
Marvin, R
We confirmed both in vitro and in vivo that specific combination of ligands of different transporters, especially alanine and glutathione, is more efficient than single ligands to facilitate the penetration of nanocarrierss across the BBB [24, 32, 33, 42]
Metabolism Metabolism affects how quickly the body uses B12