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Biochemically, ferroptosis is driven by the accumulation of lipid hydroperoxides (L-OOHs) resulting from lipid peroxidation of unsaturated fatty acids in cell membranes

They are to be refrigerated at all times

Shao Y et al

5 Circulating levels of GIP are near normal in type 2 diabetes, but the peptide has decreased ability to stimulate insulin secretion levels

This very short action limited the initial enthusiasm for the possible usefulness of incretins for the treatment of T2DM, and in turn stimulated the development of both GLP1 agonists resistant to DPP-4, with a longer half-life and of DPP-4 inhibitors that prolong the half-life of native incretins