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DSIP was chemically synthesized using a solid-phase method, with its purity (98.5%) confirmed by HPLC, NMR, and MS data
It inhibits NNMT, lowering 1-MNA formation while increasing availability of nicotinamide for NAD salvage and SAM for other methylation reactions
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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers
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