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Furthermore, the activity of ROS in breast cancer may not be limited to the mutagenic activity or reactions that lead to the initiation and progression of breast cancer alone
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The main concern is a rare, serious condition called non-arteritic anterior ischemic optic neuropathy (NAION)
H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)
There was no significant reduction in body weight compared with placebo
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