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MDS1-EVI1 Complex (MECOM) Activation Promotes Leukemic Stem Cell Quiescence By Upregulating CDKN1C/P57Kip2

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It is the only animotransferase known to utilize SAM as an amino donor Gene Name: BIO3 Uniprot ID: P50277 Molecular weight: 53708.39844 Reactions General function: Involved in methionine adenosyltransferase activity Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP Gene Name: SAM1 Uniprot ID: P10659 Molecular weight: 41818.0 Reactions General function: Involved in catalytic activity Specific function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable) Gene Name: LIP5 Uniprot ID: P32875 Molecular weight: 46246.80078 Reactions General function: Involved in methyltransferase activity Specific function: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities

European Journal of Biochemistry, 267(16), 4904-4911

CoA-LOT: BN20240403/CA