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Therefore, its safety profile has not been extensively studied or established through rigorous clinical trials
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This lack of awareness contributed to delayed diagnoses and inappropriate treatments for many patients.2 Only recently, through the development of comprehensive clinical guidelines, such as the German S2k Guidelines, lipedema has been increasingly acknowledged as a distinct medical condition.3 In the S2k Guideline, lipedema is defined as a painful, disproportionate symmetric distribution of adipose tissue of extremities occurring almost exclusively in women.3 The most affected areas include the lower abdomen, hips, buttocks, thighs, and lower legs.4 Individuals with lipedema frequently report increased sensitivity to touch, pain, easy bruising, and a sensation of heaviness or fatigue in the affected limbs.5 Its onset is often associated with periods of hormonal fluctuation, such as puberty, pregnancy, or menopause.68 The reported prevalence of lipedema varies significantly among European countries, ranging from 0.06% to 39%
It also requires reform of systems that enable pharmaceutical companies to wield patent monopolies for longer than intended in order to maximize profits at the expense of public health
Many patients can continue GLP-1 receptor agonists
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