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The STROBE reporting checklist was followed

However, certain patient populations might theoretically benefit from the anti-inflammatory properties of these agents when used for approved indications

The condition may be recognized only after sudden death has occurred

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As a follow-up to Lehninger's work several years later, Nishikimi and co-workers observed that the gene that codes for gulonolactone oxidase is actually present in humans, but is not active due to the accumulation of several mutations that turned it into a non-functional pseudogene (Nishikimi & Yagi 1991)