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Lighter individuals may achieve good results at lower doses (300-350mcg)
Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism
The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery
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