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Disruption of the intestinal mucosal barrier, alterations in the microbiota, and microbial translocation lead to systemic inflammation, further impacting the hosts immune and metabolic homeostasis [4]
It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61
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