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Acknowledgements This work was supported by the National Key R&D Program of China (2023YFC2705802 to J.W.), the National Natural Science Foundation of China (82573812 to C.C.), the Natural Science Foundation of Hubei Province (2025AFB580 to C.C.), the Foundation of Tongji Hospital, China (2023CXZH014 and 25-2KYC13057-18 to C.C.), and the China Postdoctoral Science Foundation (2025M782382 to M.X.)
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The ideal maintenance dose is the one that produces consistent weight loss with tolerable side effects
Resistance training preserves and builds lean mass during fat loss, improving body composition beyond just fat reduction
Why GLP-1 Therapy Alone May Be More Effective Long-Term Clinical trials show that semaglutide alone produces weight loss of 1022% of baseline body weight over 68 weeks, with sustained benefits lasting years when the medication is continued
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