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Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency
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In contrast, 10 studies investigated the relationship between B12 supplementation status and homocysteine levels, encompassing a total of 191 participants (mean: 19.1 per study)
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