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Pancreatitis: discontinue if suspected

Polymyxins are antimicrobial peptides that interact with the lipopolysaccharide (LPS) moiety of the membrane of Gram-negative bacteria and induce divalent cation displacement, resulting in destabilization of the membrane, loss of integrity, and cell death 3,4,5

Johns Wort is a potent inducer of CYP3A4, which can lower tacrolimus levels and increase the risk of organ rejection