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While they ideally make estrogen metabolites inactive and ready for phase II, any dysfunction in this phase may also leave them active with potentially harmful results.1 Phase I detoxification readies estrogen metabolites and other fat-soluble molecules through hydroxylation to begin their path of elimination

With improvement space the doses further apart taking a dose when symptoms start to return

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It was noted that no clinical trials had yet been completed on AD, PD, or other neurodegenerative disorders