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Mientras que GIP acta casi exclusivamente a nivel pancretico, existen receptores para GLP-1(R-GLP1) ampliamente distribuidos en el pncreas endocrino (alfa y ), en rganos perifricos (corazn, estmago, nervio vago) y en varias regiones del SNC, incluyendo el hipotlamo y el tronco cerebral

Obes Surg 2023

Expression of ASGPR1, a specific hepatocyte differentiation marker located dominantly at basolateral and sinusoidal membranes, but not at the bile canalicular membrane 28,30 , was observed in hepatocytes indicating appropriate cellular differentiation of HepaRG cells after 7 days of perfusion

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Garbuio A, Hanashiro T, Markman B et al