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Based on the profile of participants enrolled in retatrutide trials to date, the drug appears most relevant to adults living with obesity (BMI 30 kg/m) or those who are overweight (BMI 27 kg/m) with weight-related health conditions such as type 2 diabetes, hypertension, dyslipidaemia, or obstructive sleep apnoea

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378,379 It has also been proposed that the formation of inflammasomes can be inhibited by inhibiting the synthesis of adenosine triphosphate (ATP)