In the absence of vitamin B12 supplementation, unusually high vitamin B12 levels in the bloodstream may sometimes indicate underlying health conditions, including: 10 Several forms of liver disease, such as acute hepatitis, cirrhosis, and liver cancer Certain blood cancers, including leukemia and polycythemia vera Hypereosinophilic syndrome, a group of blood disorders that may lead to organ damage 11 Does Having High Vitamin B12 Levels Mean Cancer
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Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations