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It is found in at least 20% of kidney stone formation (11)
Toxicology & Safety Profiling: Assess offtarget sympathomimetic effects, renal and muscle toxicity risks, and doselimiting tolerability in animal studies PubMed
There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)
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