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The chosen specificity effectively reduced IgG recycling in cells and the IgG plasma half-life in relevant human transgenic mice and NHPs both as a full-length IgG4 and as other monovalent Fab-containing molecules [124]
They act as critical signaling molecules in the human body and are involved in many physiological functions from hormonal regulation and immune defense to tissue repair and neural communication
Cancer 142 NielsenT
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