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Oral BCAAs also improved HE manifestations across a meta-analysis of randomized trials (risk ratio 1.71, 95% CI 1.172.51), with stronger effects in overt HE (risk ratio 3.26, 95% CI 1.477.22) (69)
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In the Methods, we discussed why, based on experimental and clinical studies, we chose 80% as the increase in average activation of GCL and GPX by estradiol
