For the highest dose group (12 mg), this is what the titration schedule looked like: Weeks 1-4 : 2 mg once weekly Weeks 5-8 : 4 mg once weekly Weeks 9-12 : 8 mg once weekly Weeks 13 onward : 12 mg once weekly What phase 3 trials show so far: Testing long-term dosing of retatrutide In more recent phase 3 trials , the doses used are a bit different, but the overall structure still follows that same gradual, step-by-step pattern
Subcutaneous injection (standard) This is the gold standard for injectable semaglutide
Savica V, Santoro D, Mazzaglia G, Ciolino F, Monardo P, Calvani M, et al
Eli Lilly investigational drug
Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time