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Effects of GLP-1R activation in the heart The observation that GLP-1 decreases contractility in primary culture of adult rat cardiomyocytes, despite increasing cAMP levels, [38] has also been reported in isolated rat hearts [45]

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During pathological conditions like diabetes, COPD, and kidney disease, structural modifications of HSA induced by glucose or acrolein can strongly impair its antioxidant properties

Woo KS, Chook P, Lolin YI, Sanderson JE, Metreweli C, and Celermajer DS (1999)