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Current therapeutic strategies for these conditionssuch as oral small-molecule drugs, systemic chemotherapy, or surgical intervention are often constrained by limitations, including poor targeting efficiency, rapid drug degradation, significant off-target side effects, and difficulty in penetrating diseased tissues (e.g., tumor stroma or inflamed mucosa) [7, 8]

Additionally, Semaglutide may not be suitable for individuals with certain conditions, such as a history of thyroid cancer or pancreatitis

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