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Numerous randomized controlled trials, many in subjects with existing hyperhomocysteinemia and vascular dysfunction, have demonstrated that supplementation with folic acid, alone or combined with vitamin B 6 and vitamin B 12 , effectively reduces fasting plasma homocysteine concentration

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doi: 10.1016/j.neuropharm.2019.107813 187 KeJTianQXuQFuZFuQ

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