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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose
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Commercially available enzyme-linked immunosorbent assays (ELISA) were used for determination of total GLP-1 (736 and 936) (ALPCO, Salem, NH), GLP-2 (133 and 333) (Merck Millipore, Burlington, MA) and DPP4 (R&D Systems, Minneapolis, MN) plasma concentrations and were carried out according to the manufacturers instructions
A gradient-echo EPI sequence, TR = 1000 ms, TE = 13 ms, FOV = 20 7.9 mm 2 , slices: 13, slice thickness = 0.6 mm, matrix size = 121 48, repetitions = 480, was used to obtain resting state functional MRI (rs-fMRI) blood oxygen level-dependent (BOLD) data
Insulin Resitance in Patients With Acromegaly
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