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Outcomes would be measured with validated instruments: instrumental elasticity and firmness, corneometry and cutometry, standardized photography with blinded grading, and, most convincingly, dermal biopsies quantifying collagen density and organization before and after
Active and passive facial measures quantify changes in expressive behaviors such as facial expressions, blinking, and gaze shifts, indicating subtle phenotypic features such as masked face, reduced emotional expression, and visuogait coordination [154, 191, 192]
That distinction is the whole reason the eloralintide readout is interesting: the reported adverse-event profile in the lower dose arms was similar to placebo, which is not a sentence that typically appears next to double-digit weight reduction in this class
If it burns, its usually not the peptideits how and where its being injected
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