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Biochimica Biophysica Acta, 1741 (1-2), 48-54

This activation upregulates EAAT3 as part of the cells defense against ROS

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In the realm of cell-based therapies and antibodydrug conjugates (ADCs), CT041, a CLDN18.2-targeted CAR-T product, is being studied in gastrointestinal cancers (NCT04404595), while enfortumab vedotin, targeting Nectin-4, is under investigation for metastatic castration-resistant prostate cancer (NCT04754191)