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Semaglutide changes how quickly food moves through the digestive system, which can cause stools to become harder and more difficult to pass
These agents are believed to suppress presynaptic dopamine release and dampen postsynaptic reward signaling at mesolimbic synapses, thereby diminishing the reinforcing effects of alcohol consumption
The investigators also observed that reductions in alcohol consumption continued throughout the 26-week intervention, including after the gastrointestinal side effects commonly associated with semaglutide had generally subsided
