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This pattern is so common that researchers have given it a name: the GI tolerance paradox

The evidence is overwhelming, consistent, and reproduced across thousands of subjects in multiple rigorous trials

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In contrast, 10 studies investigated the relationship between B12 supplementation status and homocysteine levels, encompassing a total of 191 participants (mean: 19.1 per study)

Following, the complex enters the nucleus, where it binds to another transcriptional factor and to the DNA producing induction and gene rebuke, what finally leads to its anti-inflammatory, immunosuppressant and mineral corticoid effect