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Detoxification pathways in the liver
Since amitraz is considered to be an agonist in the octopaminergic system of arthropods [7], this mimicry could have resulted in its non-recognition as a foreign or xenobiotic compound and, therefore, not a metabolite of the GSTs
Inflammopharmacology 28:795817 Mehta M, Dhanjal DS, Satija S, Wadhwa R, Paudel KR, Chellappan DK, Mohammad S, Haghi M, Hansbro PM, Dua K (2020b) Advancing of cellular signaling pathways in respiratory diseases using nanocarrier based drug delivery systems
In addition, NAC treatment effectively protected primary human [46] and mouse hepatocytes [143] but not HepG2 cells against APAP toxicity [144]
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