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These advanced therapeutics hold the potential to revolutionize the management of metabolic disorders by providing sustained benefits for glucose control, weight loss, and overall metabolic health [80,81,82] (Table 1)
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Specifically, reduced expression and phosphorylation of ERK1/2, JNK1, and P38 MAPK were observed, along with decreased expression of pro-angiogenic factors (VEGF), fibroblast growth factor receptors (FGFR-1), transforming growth factor 1 (TGF-1), Snail, and hypoxia-inducible factor 1 (HIF-1)
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Many patients tolerate it well and see similar results to Ozempic or Wegovy
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