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Download high quality TIFF image Many different cell types express GLP-1R and GIPR and utilize G proteins to relay signals, but the impact of incretin binding can have vastly different results in different tissues
Tsukada, M
Some companies, including Lilly, are also exploring oral GLP-1 receptor agonists, which DIMarchi refers to as small molecule mimetrics. These molecules, however, are far more complex than traditional oral small molecules
Mounjaro works through two incretin hormone pathways, while Ozempic works primarily through GLP-1
Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM
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