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B12-containing formulations tend to have a slightly different color (often pinkish or reddish ) and can cause a mild stinging sensation at the injection site that pure tirzepatide does not produce
AMD is a leading cause of irreversible blindness in older people
Key milestones to watch: TRIUMPH-1 and TRIUMPH-2 completion: Full data from all trials needed for submission NDA submission: Analyst consensus projects Q1Q2 2027, pending TRIUMPH-1/2 primary completion in April 2026 (analyst estimate, not Lilly-confirmed) FDA Priority Review: Obesity medications may qualify for expedited review FDA approval: If granted, most optimistic projection is late 2027 Important caveat: These are analyst projections, not FDA commitments
This draws frustration from Sanders, who says that Americans are indirectly paying more for these drugs than other patients in Europe and Canada through high insurance costs
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