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The mechanism by which epitalon stimulates pineal melatonin production is not fully elucidated, but may involve activation of genes encoding enzymes in the melatonin biosynthetic pathway (particularly N-acetyltransferase, the rate-limiting enzyme for melatonin synthesis) or restoration of pineal cell function in aging tissue

Metabolic contribution to age-related chromosome missegregation in mammalian oocytes

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The initial two stages primarily involve the formation of fibrous striations through melanin deposition, while the latter two stages are responsible for the synthesis of melanin and its deposition onto these fibrous striations