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The Endocrine Society's position is clear: FDA-approved bioidentical hormones (such as Estrace, Prometrium, or transdermal estradiol patches) should be preferred over custom-compounded formulations because approved products undergo standardized manufacturing and quality control [9]

It is most effective when taken within 72 hours (3 days) after intercourse, but it can sometimes work up to 120 hours (5 days) after

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In animal models, it has accelerated wound closure and increased new blood vessel formation in injured skin