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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

If DSIP enhances deep sleep, it could theoretically amplify this natural hormone release window

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113 Central Nervous System Drug Administration and the Blood-Brain Barrier Some speculate that strong selective pressure must have existed to allow such a complex structure as the BBB to evolve