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Researchers at the University of Pennsylvania analyzed health records from roughly 12,004 adults with Type 2 diabetes who started taking GLP-1 medications between 2019 and 2024, comparing them with tens of thousands of other patients using two other diabetes drugs, SGLT-2 inhibitors and DPP-4 inhibitors

Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age

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Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-B signalling pathway

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