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May your doses stay accurate, your B12 levels stay optimal, and your progress stay consistent.

It should only be done under the supervision of a qualified healthcare provider

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Benefits were more pronounced in younger adults (under 65), women, and patients with obesity, though confidence intervals often overlapped between subgroups

The pivotal evidence for tirzepatide comes from the SURMOUNT program for weight management ( The New England Journal of Medicine , 2022) and SURMOUNT-OSA for obstructive sleep apnea (NEJM 2024), while the semaglutide STEP trials (NEJM 2021) anchor the single-agonist side