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Hepatic glutathione depletion is observed in alcohol-related liver disease, acetaminophen toxicity, viral hepatitis, and non-alcoholic fatty liver disease
References: Brown GL, Eccles JC (1934): The action of a single vagal volley on the rhythm of the heart beat
In the liver, the GSH/GSSG ratio was reduced by two-thirds and redox potential (EGSSG/2GSH) was less negative in KO mice 17
Members of our Group: Brianna Baker Reisa Guyadeen Jandell Thomas-John Nataqi Vilafanna
Therefore, NRF2 plays an important role in maintaining the cell redox balance and preventing ferroptosis
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