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1 ARR=absolute risk reduction

Taken together, metformin may upregulate PKA signalling to exert its synergistic protective effects with liraglutide in both GLP-1R-dependent and -independent manners in PA-impaired endothelial cells

In essence, GLP-1 RAs might reconfigure the epigenetic characteristics of diabetic cells, offering significant therapeutic benefits in addressing IR and reversing harmful epigenetic alterations linked to aging and metabolic disorders

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Staying at a dose that is producing consistent results with manageable side effects is clinically appropriate