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On the right bottom: GHK-Cu treated skin

Our study indicates that upregulation of p53-pS15 and p16 maintains a persistent senescent microenvironment to promote cell cycle arrest and apoptosis resistance in keloid fibroblasts

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doi: 10.3389/fmicb.2026.1771755 Received 19 December 2025 Revised 11 February 2026 Accepted 17 February 2026 Published 16 March 2026 Volume 17 - 2026 Edited by Takema Fukatsu, National Institute of Advanced Industrial Science and Technology (AIST), Japan Reviewed by Vincent Joseph Starai, University of Georgia, United States Achmad Gazali, National Agriculture and Food Research Organization, Japan Updates Copyright 2026 Yousef, Masters, Wu, Hong, ONeill, Turner, Ward and Taylor