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Like other GLP-1 receptor agonists, Orforglipron works by mimicking a hormone that targets areas of the brain involved in appetite regulation and blood sugar control
The SOUL trial (NCT03914326), investigated the effects of oral semaglutide on major adverse cardiovascular events (MACE) in patients with T2D, with or without the use of SGLT2i
Rybelsus works as a GLP-1 receptor agonist, enhancing insulin secretion and diminishing glucagon production, which contributes to weight reduction
Clinical trials of GLP-1RAs have primarily focused on patients with obesity or overweight, yet the effectiveness in the cardiovascular protection appears independent of baseline BMI range (265)
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