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In addition, iron metabolism is also regulated primarily by the liver, which maintains systemic iron balance by producing and secreting hepcidin, the master regulator of iron homeostasis [24] (Fig
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10.2337/dc19-0749 5 AtaklteF.SongR
Patients with cirrhosis often show elevated endogenous GH but reduced IGF-1 because hepatocytes cannot respond normally to GH receptor signaling
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