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Nature 607 , 563570 (2022)
But the FDA's briefing documents flagged it as an uncharacterized risk requiring further investigation before any approval, and researchers continue to weigh the angiogenic mechanism against the compound's apparent safety profile in animal models
Efficacy of uridine monophosphate, acetyl-L-carnitine and alpha lipoic acid in the treatment of pain in chronic neuropathy and radiculopathy: a review of the literature and an observational pilot study on radiculopathy
No formal human PK study has been published with full half-life determination, though a 2025 pilot study involving intravenous infusion in two healthy adults confirmed the peptide is cleared relatively quickly without measurable effects on cardiac, hepatic, or renal biomarkers (Lee and Burgess, 2025)
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